Copper-Mediated Amidation of Heterocyclic and Aromatic C−H Bonds
نویسندگان
چکیده
A copper-mediated aerobic coupling reaction enables direct amidation of heterocycles or aromatics having weakly acidic C-H bonds with a variety of nitrogen nucleophiles. These reactions provide efficient access to many biologically important skeletons, including ones with the potential to serve as inhibitors of HMTs.
منابع مشابه
Cu-Catalyzed Direct Amidation of Aromatic C–H Bonds: An Access to Arylamines
A Cu-catalyzed aromatic C-H amidation with phthalimide under oxygen as a terminal oxidant without using additional additives has been achieved. This reaction has the broad substrate scope and shows moderate to good yields in most cases. This method is complementary to the previously reported metal-catalyzed C-H amination systems.
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متن کاملConsideration of C-H…O interaction in the heterocyclic organic-inorganic hybrid material: tri-prolinium12- phosphomolibdate heteropolyoxometalate
Crystallographic data analyses indicate that three types of prolinium cations, along with two types of hydrogen bonding, produce and stabilize the helical structure of triprolinium 12-phosphomolybdate. There are similarities between this organic-inorganic compound and peptides/proteins. The stronger “conventional” hydrogen bonds and the less common C-H…O attractions play critical roles in g...
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